Originally designed in 1969 as a length of 3.488 kilometres (2.17 mi), it hosted its first event in 1972. The track length was increased to 4.064 kilometres (2.53 mi) in 1993. As of 2007, it began hosting the San Marino and Rimini Coast Grand Prix as part of the MotoGP World Championship.
On 3 Nov. 2011, the circuit owners announced that it would be named after Marco Simoncelli, an Italian motorcycle racer who died during the Malaysian Grand Prix in Sepang a week prior. Simoncelli was born in nearby Cattolica and lived since childhood in Coriano.